Xoloitzcuintlis are intelligent and intuitive, often responding to human moods and energy. They require gentle training with positive reinforcement. Harsh discipline is not suitable for this emotionally aware breed. Socialization should start early, particularly for the hairless variety, which can be more reserved.
Hairless Xolos need regular skin care—gentle bathing, moisturizing, and sun protection are essential. Their skin can be prone to dryness or irritation. Coated Xolos have short, low-maintenance fur. Overall, they are a healthy, long-lived breed with few genetic concerns, though skin issues, missing teeth, and sensitivity to cold can occur.